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BIOCOX (salinomycin sodium)

BROILER	At 180 ppm (3 times the usual dose) reduction of the feed consumption and weight.
LAYING AND BREEDER PULLET	No problem at 60 ppm. A sudden introduction at 16 weeks has caused 5% mortality (Griffith & al-1989).
LAYING HEN	25 ppm decreased the production of eggs and the feed intake. Production returned to normal after stopping the supplement. Residue in the eggs.
BREEDER HEN	At the usual dose a significant reduction of the hatchability (Jones et al–1990).
TURKEY	Maximum doses tolerated in continuous feeding: 0-12 weeks : 40 ppm +12 weeks : 20 ppm adult female : 10-15 pm A sudden introduction of 15-20 ppm before 12 weeks is badly tolerated : in the adult, dyspnoea, ataxia, myopathy and mortality in 5 to 12 hours.
DUCK	Maximum dose tolerated for fattening ducks : 100 ppm continuously.
GUINEA FOWL	Maximum dose tolerated : 120 ppm if fed from day old Sudden introduction at 3 weeks of 12-23 ppm : paralysis and mortality (Reece 1988 ).
PHEASANT	Maximum dose tolerated : 60 ppm - good anticoccidial.(Jurkovic- 1982).
QUAIL	Maximum dose tolerated : 30 - 40 ppm, paralysis and possible mortality (Reece - 1988).
PARTRIDGE	Maximum dose tolerated  40 ppm.
RABBIT	Salinomycin is authorised in fattening at 20-25 ppm. No negative results up to 50 ppm.
HORSE	LD50= 0.6 mg/kg LW- Very toxic. 4 kg of feed with 60 ppm have caused circulation and “colic” problems.
CATTLE	Preruminant – 20 ppm – No negative results. Ruminant – 60 ppm – No negative results.
SHEEP	At 40 ppm no negative results.
SWINE	Salinomycin is authorised at 60 ppm up to 4 months, 30 ppm up to 6. Is tolerated 8 times the dose continuously. No mortality at 16 times the dose in single dose.